We determined the single-particle cryo-electron microscopy structure of mammalian K(v)10.1, or Eag1, bound to the channel inhibitor calmodulin, at 3.78 angstrom ...
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What is the voltage-gated potassium channel transport?
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We present near-atomic-resolution cryo-EM structures of the mammalian voltage-gated potassium channel Kv1.2 in open, C-type inactivated, toxin-blocked and ...
voltage-gated potassium channel complex. (10). Sequence and Structure ... Single particle cryo-EM structure of the voltage-gated K+ channel Eag1 bound to the ...
The Kv4 subunits associate with KChiPs, intracellular calmodulin-like calcium-binding proteins that regulate channel gating. ... Kv1 channel complexes can carry ...
Missing: Transport- | Show results with:Transport-
Potassium channels play a role in repolarization of the membrane, which follows membrane depolarization by sodium, and in some cases calcium, channels during ...
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Nov 1, 1996 · Channel activity is inhibited by interaction with Ca2+-bound calmodulin (PubMed:27516594). Interaction of a single pore-forming alpha subunit ...
Molecular insights into the gating mechanisms of voltage ... - Nature
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Jan 31, 2023 · Here, we determine the high-resolution cryo-electron microscopy (cryo-EM) structure of human CaV2.3 in complex with the α2δ1 and β1 subunits.
In this model, the hAB-CaM complex is located at ~40 Å from the vestibule of the pore, thus, when CaM binds Ca2+, it can easily modulate the channel gating. Our ...
The Kv4 subunits associate with KChiPs, intracellular calmodulin-like calcium-binding proteins that regulate channel gating. Some of the Kv7 and Kv11 α ...
Missing: Transport- | Show results with:Transport-
CaM has long been known to modulate voltage-gated ion channels by binding to ... voltage and calcium sensor activation to opening in BK potassium channels.
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