WO1992012714A2

WO1992012714A2 - Food supplement

Info

Publication number: WO1992012714A2
Application number: PCT/NL1992/000015
Authority: WO
Priority date: 1991-01-23
Filing date: 1992-01-23
Publication date: 1992-08-06
Also published as: NL9100105A; AU1241492A; WO1992012714A3

Abstract

A food supplement on the basis of an effective combination of hydroxyapatite and vitamin C for veterinary and also human application. It may contain optionally also a salt, a boron compound and/or various other additives, known as such. The hydroxyapatite should be microcrystalline for optimal results. The food supplement is especially effective in alleviating hip dysplasia.

Description


  
 



  Food supplement.



   The invention relates to a food supplement, in particular   A    food supplement for the regeneration of bone and cartilage in mammals.



   Food supplements obtainable hitherto for providing nutritious matter for bone generation, though providing some bone improvement, have been found substantially less active in comparison with the food supplements according to the present invention. Thus it is declared, that under otherwise identical conditions calcium gluconate provides a growth and regeneration of bone and cartilage of 1.5%, while a food supplement with predominantly microcrystalline hydroxyapatite provides a growth and regeneration of bone and cartilage of 6.1%. A food supplement according to the present invention provides a substantial improvement in comparison with the best result stated hitherto, as a growth and regeneration of bone and cartilage of at least   8t    is obtained therwith under otherwise identical conditions.



   The present invention relates essentially to a food supplement having as most important active component hydroxyapatite, preferably microcrystalline, as well as addition a substantial quantity of vitamin C, suitably in a ratio of 10:1 to 1:10, preferably in a ratio of 5:1 tot 1:5 and most preferably in a ration of 3:1 to 1:3. Such preparations will provide a growth and regeneration of bone and cartilage of at least 8% with suitable dosage over a suitable period of time under conditions which correspond with those, used for determining the growth and regeneration of bone and cartilage for calcium gluconate and hydroxyapatite as such. It should be observed in this connection, that the hydroxyapatite was used previously in combination with amino acids, mucopolysaccharides, magnesium, zinc, silica, manganese and some trace minerals, as well as calcium in bonded form.

  The hydroxyapatite is used in the preparation according to the present invention either as such or in a similar combination as the known  preparation. The presence of a substantial amount of vitamin C causes a substantial improvement of the action on increase of bone and increase of cartilage in comparison with the action of the microcrystalline hydroxyapatite as such. The result thus obtained according to the invention may be improved still further by adding salts of hydroxycarboxylic acids, in particular hydroxypolycarboxylic acids or polycarboxylic acids.

  As examples of suitable salts, that may be incorporated in the preparation according to the invention are mentioned by way of example the sodium, potassium, calcium, magnesium, boron and aluminium salts of lactic acid, tartaric acid, pyruvic acid, citric acid, itaconic acid, oxalic acid, malonic acid, succinic acid and glutaric acid. The above enumeration of suitable salts should not be considered as exhaustive. On the basis of the present experience boron citrate is preferred. The salts mentioned above will provide the desired improvement by adding them in an amount of 0.5 to 5 % by weight, on the basis of the weight of the hydroxyapatite present.



   Apart from the components as mentioned above, the preparation according to the present invention may contain minor amounts of potassium, calcium, magnesium, zinc of manganese ascorbate, calcium panthotenate, calcium phosphate, magnesium sulfate hydrate, flavonoids, silica (preferably of organic origin), vitamin B6, iron fumarate, xylose and various amino acids, such as proline, lysine, cystine and taurine.



   Though the various components of the preparation according to the invention are preferably administered in a tablet, capsule or powder, as considered desirable. it will be obvious to the expert in the art, the optionally the various components, or if the circumstances demand, may be divided over two or more separate dosage units, each one comprising at least one component of the preparation according to the invention. The preparation according to the invention is especially suitable for improvement of the stability of a joint, the mobility of a joint and the power in mammals, including human beings, having the relevant  problems. Bij way of example an improvement will be obtained thereby of the charging capacity of the hind legs in the case of hip dysplasia. 

  As dosing usually 30-100 mg/kg body weight/day, divided over 3 dosages per day, will be administered over a period of at least 1 month, preferably for at least 3 monts, and if desired so much longer as the circumstances may require. Thus 3 (three) lame dogs, which had been treated for 3 months in the manner as described above, could walk and jump again undisturbed at the end of said period.



   It will be obvious to the expert in the art to make modifications or changes within the framework of what has been described above, without deviating from the inventive concept.

Claims

Claims:

1. A food supplement, characterised in that it comprises an effective combination of at least hydroxyapatite and vitamin C.

2. A food supplement according to claim 1, characterised in that the hydroxyapatite is microcrystalline.

3. A food supplement according to claim 1 or 2, characterised in that it comprises hydroxyapatite and vitamin C in a ratio of 10:1 to 1:10.

4. A food supplement according to claim 3, characterised in that the ratio is from 5:1 to 1:5.

5. A food supplement according to claim 4, characterised in that the ratio is from 3:1 to 1:3.

6. A food supplement according to one or more of the preceding claims, characterised in that it comprises in addition a salt of a hydroxycarboxylic acid, a polycarboxylic acid or a hydroxypolycarboxylic acid.

7. A food supplement according to claim 6, characterised in that it comprises boron citrate.

8. A food supplement according to claim 6 or 7, characterised in that it comprises the salt in an amount of 0.5 to 5 % by weight, on the basis of the weight of the hydroxyapatite present.

9. A food supplement according to one or more of the preceding claims, characterised in that it comprises in minor amounts one or more of the following components: potassium, calcium, magnesium, zinc and manganese ascorbate, calcium panthotenate, calcium phosphate, magnesium sulfate hydrate, flavonoids, silica, vitamin B6, iron fumarate, xylose and various amino acids, such as proline, lysine, cystine and taurine.

10. Application of a food supplement according to one or more of the preceding claims, characterised in that it is administered in the form of a tablet.

11. Application of a food supplement according to one or more of the preceding claims, characterised in that it is administered in the form of a capsule.

12. Application of a food supplement according to claim 10 or 11, characterised in that it is administered in an amount of 30/100 mg/kg body weight/day.

13. Application of a food supplement according to one or more of the claims 10-12, characterised in that the food supplement is subdivided in separate entities, each one comprising at least one main component.