Retrospective Evaluation of Cases Diagnosed with Ulcerative Colitis/Ulseratif Kolit Tanili Olgularimizin Retrospektif Olarak Degerlendirilmesi.

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From: The Journal of Current Pediatrics(Vol. 10, Issue 1)
Publisher: Galenos Yayinevi Tic. Ltd.
Document Type: Report
Length: 4,164 words

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Abstract :

Introduction: Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal canal characterised by remissions and exacerbations. This study aimed to make a retrospective evaluation of clinical and laboratory findings of patients being monitored with a diagnosis of IBD. Materials and Methods: Medical records of 18 patients with a diagnosis of IBD and 7 years of follow-up at our pediatric gastroenterology departments were investigated with respect to demographic data, complaints on presentation and accompanying diseases. Unusual findings from physical examination, endoscopic findings, histopathological findings and the applied treatments were examined. Results: The 18 patients (10 female, 8 male) included in this study had a mean age of 13.6 [+ or -] 2.9 years and the mean time from onset of symptoms to diagnosis was 6.9 [+ or -] 4.5 months. Seventeen patients were diagnosed with ulcerative colitis and 1 patient with intermediate colitis. There was a positive family history of the disease in 2 patients (11%). At the time of diagnosis, the most common complaints on presentation were found to be abdominal pain (100%), bloody diarrhea (94.5%) and tenesmus (44.4%). The most frequent laboratory findings were CRP positivity (89%), increased sedimentation rate (83.3%) and iron- deficient anaemia (77.7%). On colonoscopy, pancolitis involvement (66.6%) was most frequently encountered. Accompanying diseases to IBD were found to be familial Mediterranean fever (FMF) (11%), celiac disease (5.5%) and Heliobacter pylori gastritis (5.5%). One patient (5.5%) who did not respond to medical treatment for pancolitis involvement underwent a colectomy. Discussion: The number of diagnoses of IBD in childhood is gradually increasing. Nonetheless, it can be difficult to define diseases with non-specific symptoms and this may cause a delay in diagnosis. Because of the association of autoimmune diseases with IBD, despite appropriate therapy, diseases with no remission which lead to gastrointestinal inflammation, such as FMF, should be further investigated. Key words: Inflammatory bowel disease, ulcerative colitis, remission Giris: Inflamatuvar barsak hastaliklari (IBH), gastrointestinal kanalin remisyon ve alevlenmeler ile seyreden kronik inflamatuvar hastaliklaridir. Calismamizda IBH tanisi ile izledigimiz hastalarin klinik ve laboratuvar ozelliklerinin geriye donuk olarak degerlendirilmesi amaclanmistir. Gerec ve Yontem: Cocuk gastroenteroloji bolumlerimizce 7 yildir IBH tanisi ile izlemleri yapilan 18 hastanin basvuru yakinmalari, demografik ozellikleri ve beraberinde bulunan hastaliklar kayitlardan incelendi. Fizik bakida saptanan olagan disi bulgular endoskopik bulgular, histopatolojik bulgular ve uygulanan tedaviler gozden gecirildi. Bulgular: Calismamiza alinan 18 hastanin tani yasi ortalamalari 13,6 [+ or -] 2,9 yil (10K, 8E) ve semptomlarin baslangicindan taniya kadar gecen sure ortalama 6,9 [+ or -] 4,5 aydi. Onyedi hasta ulseratif kolit (UK) ve bir hasta da intermediate kolit (IK) tanisi almisti. Iki hastada (%11) hastalik acisindan pozitif aile oykusu vardi. Tani aninda en sik basvuru yakinmalari karin agrisi (%100), kanli ishal (%94,5) ve tenezm (%44,4) olarak bulundu. Laboratuvar bulgularindan CRP pozitifligi (%89), sedimantasyon yuksekligi (%83,3) ve demir eksikligi anemisi (DEA) (%77,7) en sik rastlanan bulgulardi. Kolonoskopik olarak en sik pankolit (%66,6) tutulumuna rastlandi. IBH'na eslik eden diger hastaliklar ise ailevi Akdeniz atesi (FMF) (%11), colyak hastaligi (CH) (%5,5) ve Helikobakter pylori gastriti (Hp) (%11) olarak bulundu. Pankolit tutulumu olan medikal tedaviye yanitsiz bir hastamiza (%5,5) ise kolektomi uygulandi. Sonuc: Ulkemizde cocukluk caginda IBH tanisi alan hasta sayisi her gecen gun artmaktadir. Yine de nonspesifik semptomlar ile seyreden hastalarin taninmasi guc olabilmekte ve tani gecikmelerine neden olabilmektedir. IBH'nin otoimmun hastaliklar ile birlikteligi nedeniyle uygun tedaviye ragmen remisyon saglanamayan hastalarda gastrointestinal inflamasyonla giden FMF gibi hastaliklar da arastirilmalidir. Anahtar kelimeler: Inflamatuvar barsak hastaligi, ulseratif kolit, remisyon
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Gale Document Number: GALE|A689995341