Alternatived Products of [ 100675-76-1 ]
Product Details of [ 100675-76-1 ]
CAS No. : | 100675-76-1 |
MDL No. : | |
Formula : |
C13H8INO
|
Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
321.11
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Pubchem ID : | - |
Synonyms : |
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Safety of [ 100675-76-1 ]
Signal Word: | |
Class: | |
Precautionary Statements: | |
UN#: | |
Hazard Statements: | |
Packing Group: | |
Application In Synthesis of [ 100675-76-1 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 100675-76-1 ]
- 1
-
[ 100675-76-1 ]
-
[ 51073-69-9 ]
Yield | Reaction Conditions | Operation in experiment |
70.6% |
With iron; acetic acid at 55℃; for 0.5h; |
|
- 2
-
[ 51073-69-9 ]
-
[ 100675-76-1 ]
Yield | Reaction Conditions | Operation in experiment |
|
With oxone In water; acetonitrile at 20℃; for 23h; Green chemistry; chemoselective reaction; |
Oxidative Cyclization of 2-Aminoacylbenzenes 1; Typical Procedure
General procedure: Oxone (0.270 g, 0.44 mmol) was added to a solution of (E)-1-(2-aminophenyl)-3-(4-fluorophenyl)prop-2-en-1-one (1g) (0.106 g, 0.44mmol) in MeCN/H2O (2.5 mL/2.5 mL). The mixture was stirred at r.t. and the progress was monitored by TLC and GC-MS. After stirring for 24 h, H2O (150 mL) and CH2Cl2 (150 mL) were added. The organic layer was separated and the aq layer was extracted with CH2Cl2. The combined organic layers were washed with H2O, dried over Na2SO4, filtered and concentrated. The filtrate was evaporated and subjected to column chromatography on silica gel (n-hexane/EtOAc, 98:2) togive 2,1-benzisoxazole 3g. |
- 3
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[ 175391-06-7 ]
-
[ 100675-76-1 ]
-
[ 2599852-26-1 ]
Yield | Reaction Conditions | Operation in experiment |
65% |
With copper(I) bromide In 1,2-dichloro-ethane at 80℃; for 3h; Sealed tube; |
3.2. General Procedure for the Synthesis of 3
General procedure: In a sealed tube, a solution of diaryliodonium salts 1 (0.3 mmol), isoxazoles 2 (0.45 mmol), and CuBr (20 mol%) in 1,2-dichloroethane (DCE) (2 mL) was stirred at 80oC for 3 hours without exclusion of air or moisture. After completion of the reaction (observed on TLC), the solvent was evaporated under reduced pressure to obtain the crude mixture. The residues were purified by silica-gel column chromatography (Ethyl acetate/Petroleum ether = 1/6 - 1/2) to afford the pure product 3. The obtained product was analyzed by 1H NMR, 13C NMR and HRMS. |