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4-Bromo-thiazol-2-ylamine (CAS 502145-18-8)

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CAS Number:
502145-18-8
Molecular Weight:
179.04
Molecular Formula:
C3H3BrN2S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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4-Bromo-thiazol-2-ylamine is a heterocyclic compound widely employed in scientific research, particularly in the fields of biochemistry and physiology. It serves as a crucial intermediate in the synthesis of various compounds and finds numerous applications, including drug development, biological assays, and investigations into biochemical and physiological effects. In scientific research, 4-Bromo-thiazol-2-ylamine has been instrumental in the examination of enzyme kinetics, drug binding, and the advancement of novel drugs and biological assays. Furthermore, it has contributed to the exploration of diverse biochemical and physiological processes, encompassing signal transduction, gene expression, and the regulation of cell growth and differentiation. Although the precise mechanism of action of 4-Bromo-thiazol-2-ylamine remains incompletely understood, it is believed to function as an inhibitor of enzymes involved in drug and compound metabolism. Additionally, it is thought to act as an agonist for specific G-protein coupled receptors, potentially accounting for its effects on biochemical and physiological processes.

References:

  1. Crystal Structures and Structure-Activity Relationships of Imidazothiazole Derivatives as IDO1 Inhibitors.  |  Tojo, S., et al. 2014. ACS Med Chem Lett. 5: 1119-23. PMID: 25313323
  2. Preparation of 3,4-Substituted-5-Aminopyrazoles and 4-Substituted-2-Aminothiazoles.  |  Havel, S., et al. 2018. J Org Chem. 83: 15380-15405. PMID: 30458618
  3. Unique Sulfur-Aromatic Interactions Contribute to the Binding of Potent Imidazothiazole Indoleamine 2,3-Dioxygenase Inhibitors.  |  Peng, YH., et al. 2020. J Med Chem. 63: 1642-1659. PMID: 31961685
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